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Depolarization block induction via slow NaV1.1 inactivation in Dravet syndrome

Lemaire, L.; Desroches, M.; Rodrigues, S.; Campillo, F. (2025-08-25)

Dravet syndrome is a developmental and epileptic encephalopathy, characterized by the early onset of drug-resistant seizures and various comorbidities. Most cases of this severe and complex pathology are due to mutations of...

Computational Modelling of Thixotropic Multiphase Fluids

Ellero, M.; Moreno, N.; Espinosa-Moreno, S. A. (2025-01-01)

Multiphase systems are ubiquitous in engineering, biology, and materials science, where understanding their complex interactions and rheological behavior is crucial for advancing applications ranging from emulsion stability...

On tool wear optimized motion planning for 5-axis CNC machining of free-form surfaces using toroidal cutting tools

Kruppa, K.; Zaragoza, J.; Bizzarri, M.; Barton, M. (2025-01-01)

We propose a computational framework for motion planning for 5-axis CNC machining of free-form surfaces. Given a reference surface, a set of contact paths on it, and a shape of a toroidal cutting tool as input, the proposed ...

On design, analysis, and hybrid manufacturing of microstructured blade-like geometries

Antolin, P.; Bonneau, G.-P.; Buffa, A.; Calleja, A.; Elber, G.; Elgeti, S.; Escudero, G.; Gonzalez, A.; Gonzalez, H.; Hahmann, S.; Hirschler, T.; Hong, Q.-Y.; Key, K.; Kim, M.-S.; Kofler, M.; de Lacalle, N.; de la Maza, S.; Barton, M.; Zwar, J.; Rajain, K. (2025-09-01)

With the evolution of new manufacturing technologies such as multi-material 3D printing, one can think of new type of objects that consist of considerably less, yet heterogeneous, material, consequently being porous, lighter...